I believe there are, especially with the marshmallow update. I recently noticed that you can not go online while on a phone call if advance calling is off, which is suppose to help making phone calls clearly, but in reality has made my phone calls drop and make people on the other line not hear me or sound mumbled.
Also, once on a phone call, and advance calling is on, you can not turn your mobile data on. So if you are trying to GPS, you are screwed. It seems they are pushing more and more for users to use their mobile data rather than Wi-Fi. Profits over customer service seems to be their new motto